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At least things are going in the right direction! I am reading a book by Ted Neill who spent time in Africa working with kids affected by HIV. His story is compelling and heartbreaking, but it is something that we need to keep in our minds so we can push for a way to keep these children from contracting this. His book is called Two Years of Wonder, it affected him so much seeing these children dying that it actually plummeted him into a deep depression which for him added insult to injury. I probably couldn’t handle see the devastation caused by this to those kids.
Fostemsavir, another drug for the treatment of drug-resistant HIV, prevents HIV from attaching to CD4 cells by sticking to the virus, not the cell. It prevents a change of shape of HIV’s gp120 protein that is necessary for it to lock on to the CD4 receptor. Fostemsavir, is not licensed yet.
In this background, can Fostemsavir be further developed to use as latency reversing agent to clear HIV reservoirs?
A Hiv prevention strategy, Is this a new story in the fight against HIV/AIDS? Since the world is striving to find new HIV treatment methods to end the pandemic permanently by the year 2030 or before it.
Various research are underway to develop either functional or permanent cure through bnAb, HIV vaccine, organ transplant therapy, Long acting ART etc so that the pandemic can be eradicated at this generation level only without buck passing the responsibility on to the next generation level.
Therefore, scientific and research oriented findings may be promoted so that new ideas and creativity may flourish to end the pandemic at the earlier.
Excellent overview of where we are and where we are going. We must always remember the lesson of polio which is that bringing the epidemic under effective control was succesfully achieved but finding and treating the last few cases was, in some ways, an even greater challenge. For HIV we have drugs that are effective, have minimal side effects, do not lead to drug resistance, render one uninfectious to others, reduce the risk of TB by about 60% and, at least in developing countries, cost about US$1.50 per week. We can and must end the epidemic of HIV throughout the world.