I’m hesitating over this one question I want to ask the scientist on the phone, a federal researcher studying the health effects of soy formula on infants. I worry that it’s going to sound slightly Dr. Frankenstein-esque. Finally, I spill it out anyway: “Are we talking about a kind of accidental experiment in altering child development?”
The line goes briefly silent. “I’m a little worried about the word ‘experiment,’” replies Jack Taylor, a senior investigator at the National Institute of Environmental Health Sciences, a division of the National Institutes of Health. Taylor and his colleagues in North Carolina have been comparing developmental changes in babies fed soy formula, cow-milk formula, and breastmilk. His group’s most recent paper, “Soy Formula and Epigenetic Modifications,” reported that soy-fed infant girls show some distinct genetic changes in vaginal cells, possibly “associated with decreased expression of an estrogen-responsive gene.”
But his first reaction is that my phrasing would, incorrectly, “make it sound like we were giving children a bad drug on purpose.” The research group, he emphasizes, is merely comparing the health of infants after their parents independently choose a preferred feeding method. No one is forcing soy formula on innocent infants.
“No, no, that’s not what I meant,” I explain with some hurry. “I wasn’t suggesting that you were experimenting on children.”
Rather, I was wondering whether we as a culture, with our fondness for all things soy, have created a kind of inadvertent national study. Soy accounts for about 12 percent of the U.S. formula market and I’ve become increasingly curious about what this means. Because the science does seem to suggest that we are rather casually testing the effect of plant hormones on human development, most effectively by feeding infants a constant diet of a food rich in such compounds.
Research shows that soy milk and soy formula contain up to 4,500 times the level of phytoestrogens found in cow’s milk or breastmilk. That’s a notable number. And it’s been associated with remarkably high levels of these compounds circulating in the bloodstreams of soy-fed infants. All of this matters when you consider that phytoestrogens are potent human endocrine disruptors, binding efficiently to the estrogen receptors found in both females and males. And consider further, that a baby on a soy formula diet is being repeatedly dosed every day.
It’s no wonder then that studies far beyond Taylor’s have found indicators of off-kilter developmental changes, ranging from unusually early menstruation to mammary gland effects.
In light of all this, Taylor reconsiders my point. “Well, you are absolutely correct that these babies are getting a lot higher dose of a known estrogenic compound than they’ll ever get from BPA or an endocrine disruptor like that.” And he considers a little more. “In that sense, it could be considered a kind of experiment.”
Let’s drop back for a minute. The idea that plant hormones — such as genistein, the primary phytoestrogen in soy — can interfere with mammalian development is not new. Biologists have been trying to sort out such effects for more than half a century; one of the first such studies followed the rather startling discovery that sheep grazing on fields dense with a hormone-rich clover could become temporarily sterile as a result of their diet.
Heather Patisaul, a biology professor at North Carolina State University who specializes in the study of endocrine disruptors, notes that similar effects can be seen in humans: Young women who consume a diet exceptionally high in soy also occasionally “shut off their menstrual cycles” and become temporarily infertile. “When we think about endocrine disruptors, we have to remember that they aren’t all synthetic compounds,” she emphasizes. “Soy is both a natural food and a hormonally active one.”
Cultures with a long-time reliance on soy protein apparently realized this early, Patisaul adds. For instance, the compounds in soy are known to interfere with the body’s uptake of iodine, an element necessary for healthy functioning of the hormones produced by the thyroid gland. Chinese farmers first cultivated soybeans about 1100 B.C., so it’s not surprising, she notes, that many Asian diets gradually evolved to contain foods that contain extra high levels of iodine, such as seaweeds.
Evidence of soybean cultivation in North America dates back to colonial days, but the crop was largely considered one for animal feed. It wasn’t until the late 19th century that the first recipe for dining on soy “peas” (cooked with bacon, salt, and butter) was published by an agricultural research station. And it wasn’t until the 21st century that soy foods took off as a diet staple.
The Soyfoods Association of North America estimates that product sales rose from $1 billion a year in 1996 to $4.5 billion in 2013. “More than 75 percent of consumers perceive soy products as healthy,” according to one industry survey.
The embrace of soy appears driven both by an increased shift to vegetarianism and by high-profile research showing that a diet high in soy can have a positive effect on heart disease. The main unanswered question there, Patisaul says — and one that’s been difficult to tease out — is whether reductions in heart disease are due to some aspect of soy chemistry, or due to a reduction in eating meat.
The reasons infants are fed soy formula, though, are different. Doctors may recommend it as an alternative to breastmilk or cow-milk formulas if a baby appears lactose intolerant or has some other digestive upset related to feeding. Some parents choose it because they believe it is healthier and others because they themselves have rejected an animal protein diet for ethical reasons and want to raise their children in that model. It’s such decisions — and the resulting rise in numbers of soy-fed infants — that led researchers themselves to wonder whether a steady diet of a phytoestrogen-rich food would be entirely benign for children in the early stages of development.
A 2003 paper did conclude that the primary estrogenic hormone in soy was not as endocrine-disrupting as DES (diethylstilbestrol), a synthetic estrogen once used to prevent miscarriages and early pregnancy that was later found to put both mothers and children at risk of developing reproductive system cancers. But scientists still worried that they didn’t actually know how plant hormones might affect a developing human system. A review published that same year, comparing breastmilk and formula fed infants, warned of possible adverse effects but concluded that “the science is insufficiently developed at this time to allow a credible assessment of health risks to infants.”
Another more comprehensive review published the following year simply concluded that more research was needed.
Eventually, the National Toxicology Program — a federal project to assess potentially toxic chemical compounds — took on a comprehensive assessment and in 2010 sought to reassure scientists and parents alike. The NTP concluded that soy formula should be considered of “minimal concern” in terms of developmental toxicity, and while Andrew Rooney, an NIEHS researcher who worked on the evaluation, concedes that scientists of a decade ago lacked full ability to see the kind of minute genetic shifts that are detailed in the work of Jack Taylor and other researchers, he still sees soy as a minor health concern.
At the same time, Rooney acknowledges that as the science becomes more advanced, new questions about soy — and new research into its impacts on human development — are continually arising. In 2014, researchers from the NIEHS reported that six-month-old girls raised on soy formula showed clear signs of estrogen-driven changes in reproductive system cells. The study noted: “These vaginal cell changes suggest that an exclusive soy diet is associated with a response in young girls that is consistent with physiologically active estrogen exposure.”
Two studies published in the following years found a clear association between early soy exposure, the growth of large uterine fibroids later in life, and unusually heavy menstrual bleeding. The latter report made a point of emphasizing the vulnerable timing. “Our results support the idea that infancy is a susceptible developmental window for female reproductive function.”
Which brings me back to my original question.
I spent some time reading through a raft of these papers, including Taylor’s elegant discussion of a chemical mechanism by which phytoestrogens might tinker with human gene expression. And at some point, as one paper led to the next, their range and cumulative weight started to have the feel of a large-scale, if wholly inadvertent experiment in child development. It’s worth noting along these lines that while most studies suggest a more direct effect on girls — who, not surprisingly, possess more estrogen receptors — there are also some hints of subtle effects on boys, ones that the NIEHS scientists hope to study further.
While Taylor does not dismiss the idea that parents and their children may be participating in something of an ongoing, unsanctioned experiment on the impacts of soy, he quickly expresses caution about how strong the experimental results are at this point. “We have these hints in humans that this early exposure to estrogens may have long-term consequences,” he tells me, adding that it would be a mistake to scare parents into making some other choice, because the findings on soy are still so subtle, and so new. “We were very careful not to go to ‘don’t use’ in our paper,” he says. It’s too early to do that.
But there are indications that parents are becoming more wary. While soy accounts for 12 percent of the market now, in 1998 the American Academy of Pediatrics set that number at 25 percent. And some researchers — including Patisaul — have decided the enough is known to begin sounding additional warning notes. Most people, she says, just aren’t aware that soy is such a hormonally active food, and she’d like to raise a little awareness on that front.
“When I talk to parent groups, I know that a lot of people are choosing soy formula for vegetarian or ethical reasons,” she says. “I try to advise against that, to say that it shouldn’t be used unless it’s a medically necessary choice.”
Deborah Blum is a Pulitzer Prize-winning science writer, the director of the Knight Science Journalism Fellowship Program at MIT, and the publisher of Undark.
Thank you for the information and also to all posting.
I’ve been concerned for years about the soy formulas the hospitals and pediatricians suggested my wife and I give to our newborns. Well, my wife wasn’t excited about breast feeding and then had breast feeding difficulty. She tried a pump but then it was agreed that we would just use the formula suggested.
I’m of the curious/common sense/naturalist side of decision making. However, since the hospitals and pediatricians suggested using the soy formulas and it was widely available and nobody said to be concerned, we fed both our children the soy formulas.
Bith our children measured almost identical at birth and were both two weeks late. Our daughter was first and and got plump during her first two years. Our son stayed skinny.
Then came the lawsuits from multiple prisoners suing the prisons for serving them soy based meals. In the original reporting I heard them state it was to lower the testosterone therefore lowering the aggressiveness of male prisoners. Now my curiosity levels spiked again. Our daughter was born in 1995 and our son 1999 on almost the exact same day.
As they went through puberty, I noticed my daughter was built more like a young man stockier with hair on her arms more prevalent. She never really dated in JR high or high school and has only dated one guy very briefly and she is in her mid twenties. Our son has breasts that resemble more of a female and it’s obvious and he also never dated in JR. high or high school. So, I wondered more about my son being changed by the soy formula as this is fed to them at the most important time of development of the sexual organs. I believe 100% that these formulas were developed for a reason. A reason kept secret from the public. At this point I can conceive it very likely that these were developed to assist in controlling the World’s human population. The process is working and the number of homosexuals has exploded as well as publicity to normalize the condition/behavior.I’ve noticed without a doubt homosexuality not only being being approved of but also promoted. Then abortion comes to mind and the government is allowing babies to be killed basically up to birth and certainly beyond the time a baby can survive outside the womb. So, less visible and more subtle physical changes to the sexual organs is certainly less obvious and seemingly less evil to the eyes and mind of the public. And it’s also more difficult to prove in a case by case basis which isn’t the case with abortion. It’s not only an experiment, it’s an outright project that has succeeded to prove the creators theory correct. I just hope that our children have the mental capability to accept what has happened to them and understanding to forgive us for feeding them these soy formulas. There is proof soy changes the chemical make up of the human body and the changes of the sexual organs and these changes especially in newborn humans is multiplied exponentially. It’s not the first Great experiment and certainly won’t be the last. If it’s sounds too good to be true it probably is. If it looks like a fake it’s probably a fake. How much money has been made selling these formulas? These formulas have had to be locked up in retail stores to prevent theft of them. I’m just very glad that somebody has been investigating and attempting to put honest studies together. It seems though with such a mass production and distribution to our innocent and helpless newborns that more and more large scale studies would have been forced to be created by the producers ensuring our children aren’t and won’t be physically or mentally changed and if they are production and distribution would halt immediately.
So being a poor brown person in fairly great athletic shape with good body awareness I have ran into Gerber Soy formula on a super-sale.
I read the ingredients with interests and concerns. Noticing the formula had amino acids and a few vitamins I decided to pick a container up for myself for bodybuilding. I’ve had maybe 4 servings and have noticed things going array in my body.
I then used the restroom and my urine was light blue. I went to research the formula to see if there were was a recall but no news about it. The milk also smells and tastes like goat milk which raised even more concern of the products’ legitimate cause. Doing research I came across multiple cancer causing, feminizing, kidney stone-creating studies from the ingredients in the formula going as deep as mutation and retardation.
I’m pretty sure this is sold to poverty dwellers and to feminize brute slaves into submissive individuals. I honestly feel like a lesbian just consuming around 40% of the 12.9/366gram container of Gerber Soy and iron. I drunk 3 scoops last week then today during exercise I consumed 6 scoops. Blue urine showing up 40minutes afterwards along with abnormal feeling. (I’m a habitual exerciser and know what I’m saying)
Learning about mass phytoestrogen in the product answered my experience in totality
The blue urine really set off the alarm and that happened today. I’m feeling much weaker in every way and knowing my diet/ routine I should be in a state of more strength physical and mental.
The soy movement has to be identical to the ones of vaccination. I’m not against vaccinations but being raised as a sex slave under Nazi government I know of the things they do to commoners/peons.
Soy formula is scientifically harmful to adults … Using on babies… That is tenfold. I was mislead about soy and have been learning a lot about it today.
There must be more awareness on such product and the demonstration of soy as being a good product… It’s like the kale movement saying 7grams of protein per serving. Kale grows in abundance, it’s false marketing. Kale has no muscle building compounds as it is demonstrated to be.
I found out recently my parents fed me
Soy formula as an infant and I worry it had adverse effects. I’m a 28 year old man and growing up I was always very thin, did not seem to put on muscle just “naturally” as other guys did (always had to put in crazy workouts just to get any kind of results) and had persistent flab in the chest area even when thin. Regular strength training and dietary changes have improved this to a large degree and for a long time I just though I got unlucky with my genetics but now I wonder if the soy played a part. It’s depressing cause my parents actually fed me soy formula based on the advice of their doctor,soas frustrated as I am about it, it’s not entirely fair to hold it against them. What’s done is done, but I wonder if they have been additional studies that help tease out this connect more and/or if there are any possible treatments for folks later in life who might need to get their hormones back in balance. Not really sure what I’m supposed to do with this troubling information and frankly feeling pretty bummed out :/
Hi Daniel – So far, as I hope the article indicates, the strongest evidence for the effects of intensive soy feeding to infants focus on cellular changes in the reproductive tract. The studies there are fairly compelling for human cells that have estrogen receptors and therefore might respond to the phytoestrogens in soy. Women tend to be more acutely tuned to this hormone so the studies have primarily focused on females. Men do have estrogen receptors, of course, and there are some studies underway in that regard but so far I haven’t seen any conclusive results. But again, these would likely be reproductive tract changes. I’m a toxicology journalist and not a scientist but in reading the literature, I haven’t seen any strong evidence of the kind of health effects you cite. Granted we’re still figuring this out but, for now, I’d file it as a very slightly possibility and I wouldn’t let it bum me out too much.
I have two sons ages 38 and 41. The older boy was aggressive and competitive while the younger was extremely passive. After reading the article below, I recalled that our youngest son was fed baby formula exclusively. I found out he was gay about 20 years ago. It would be tragic if soy products have indeed altered the lives of millions of children around the world.
Thank you for your efforts in bringing this to light.
Thanks so much for reading it and considering some of the important issues it raises. My impression – at least what I see in the science so far – is more of a focus on physical changes than on behavioral ones. But you are correct that hormones do affect behavior in interesting ways and I think it’s an issue worth following. At the moment, I don’t think the evidence is there and I hope that’s reassuring.
My son, now 43, was fed as a baby on soy milk, due to a sensitivity for cow’s milk and other baby formulas. He drank soy milk for about one and a half year.
He is married now for 16 years, and can’t have children. His sperm count is low. The blame for this is placed on the soy milk baby formulae. Can this be true?
There have been some studies linking soy intake to reduced sperm count and I’ll link to one here. But as you’ll see it’s look at high soy intake for men during times when they are their partners are trying to get pregnant. We’re still trying to figure out the effects of high soy intake on young male infants and toddlers so I would call that possible but not proven and not be too hard on anyone involved in such a decision. And I would add that this is research that definitely needs to be done so that we can make much more informed decisions than we have been making. Hope this helps.
I’m surprised that the parents of children who cannot tolerate cow’s milk haven’t considered goat’s milk. I live in the UK and goat’s milk is sold as formula as well as milk. It may be a less worrisome alternative to soy.
Hello.. interested reading! I have introduced soy milk to my daughter 1.5 years old. There is so much on the internet.. all mixed up. She was EBF till 6 months and continue even now.. but could you throw some light on when is it safe to introduce and quantity that will not cause the above mentioned changes… Thanks
Well, being exclusively breast-milk fed until six months is great for health. The real issue with soy formula is when it is the only food given to a very young human in the early stages of development – then you are essentially getting a high dose of endocrine-disrupting compounds. At one and a half years, I assume you are mixing it with other foods and it’s not the only source of nutrients. The best rule on protective eating is to mix it up – don’t consume too much of the same material too often because that can really amplify an exposure. As you know, zero to three years old is considered a fundamental time period in child development so I would use such a common sense approach especially until then. That’s not I should emphasize medical advice as much as, as I said, common sense from a toxicology perspective.
Informative article, thank you.
I was fed only soy formula at birth in 1958, for six months, per doctor’s instruction to my mother. Sixty years later, I’m in the eleventh year of severe and constant, 24/7 hot flashes. I believe the two are related. I’ve tried every possible remedy 5o no avail.
Thanks again for the thoughtful article.
I hope you get a break with those hot flashes, Jane. And thanks for the kind words. The research here is in the early stages but I think it’s important – and important to raise awareness. Take care.
My (then) son was born prematurely, could not nurse, and reacted badly to standard formula. He grew up fairly healthy and stable until he became a vegetarian at 16 after which he developed depression which worsened until he transitioned to female at around 32. She is now much happier. I worked in the aquarium trade during the early 1990s, and read about hormone disruption in amphibians due to agricultural and hormone-based chemicals in the environment. Whilst I am tempted to ascribe the prevalence of transgender individuals, including my own offspring to dietary soy, I suspect the answers are complex and interrelated.
I think we’re just starting to figure out some of these effects and how influential they are. The interaction of biology and behavior is, as you say, enormously complicated and, so far, not entirely understood. But it’s encouraging that we are supporting thoughtful research into these issues.
My daughter was born prem (toxaemia) in ’89 by emergency caesarian after planning a natural home birth ~ at a time when hospitals did not allow Mothers to stay with the babies, hence breastfeeding became difficult. She was breastfed for a short time – maybe a month, then onto milk formula. She developed cholic on cow milk and I switched to soy formula until she was on solids. She has been healthy in every way up until about 6 years ago after she gave birth to her own child. She overheats massively all the time. Unable to handle wearing sleeves only sleeveless clothing. Where do we begin with testing to find an answer to her problem? I have suggested to her thyroid and hormone as to what I believe her problems stem but no Dr has tested her for anything specific and it is beginning to really worry me. While she was pregnant she had an incident where she lost sight in one eye. An MRI revealed nothing.
I would consult an endocrinologist to see if there is a hormonal issue. We certainly can see that with over-heating. I don’t know that there’s necessarily a soy connection – those effects tend to be more related to the reproductive system – but the endocrine system itself is complex and important in over all health.
My son in the 80’s was constantly vomiting on formulas, never kept any dairy based formula down , and he was given Prosobee as his full time alternative , he drank that with other foods until he was around 4.
He developed small breast like tissue at around 10 as he put on weight .
Now at age 37 he has what his wife call man boobs even when slim . I feel that reading about side effects of Soy fed babies may have caused it. His brother grew up on normal milk and is perfectly normal with male pecs .
Is there a way to reverse the effects of the soy fed to him at an early age .
Is there anything one can do. I know he does get embarrassed at times.
Dear Annika – So sorry for this belated response. There are treatments to counter these kinds of hormonal effects but they are very specific to the person and the particular biochemistry at work. I would talk to an endocrinologist because this is their particular field of study and see if they could recommend counter measures. I was just at the Endocrine Society national meeting and this was definitely one of the topics under discussion.
There is a rare metabolic genetic disorder named Galactosemia. Anyone with this condition cannot have any animal or human milk. So as an alternative, the infant must be put on soy or an elemental formula. Girls with this also have a much higher chance of premature ovarian failure and infertility. So this is a huge issue for those girls. Very interesting!
Thank you for the interesting article. Since soy appears to affect the developing reproductive system, has there been any research into a link between the rise in soy formula use and the rise in homosexuality and transgender people?
Interesting question. I haven’t seen any such research although, at this point, most of the research is focused on changes at the cellular/physiological level with impacts on things like menstruation and some structural changes at the very small level. I haven’t seen anything that indicates that research at the behavioral level would make sense – and I’m thinking this is such a small percentage of the population – some 11-12 percent of people who use formula, that it probably wouldn’t have a major impact in that direction anyway. But it’s always worth considering such possibilities and as a follow the research, I’ll keep that in mind.
Neither of my daughters, now ages 19 and 22, could tolerate cow’s milk formula and were not avid nursers. I also have a cow’s milk sensitivity. I raised them on soy until they ate solid foods, and they are quite healthy, do not have any problems with female concerns like breast development or periods. Everything about them is normal. So maybe the problems aren’t just coming from soy formula? Both of my daughters are quite physically fit (dancing, swimming, water polo, gymnastics), and when we did introduce milk in our household, it was free of hormones etc. I wonder more about people feeding their kids those hormone-saturated dairy milk products than I do about a few months of soy formula.
So here’s a key point from in putting these kinds of studies in perspective: It’s important to recognize that not everyone will be similarly affected by a given environmental exposure. Geneticists will tell you that individual variation – the way each person’s genes express in response to toxic exposures or or stress or other environmental factors – is one of the biggest factors. It’s the reason why, for instance, some people don’t develop tobacco-related cancers while many others do. It’s the reason that clinical trials for drugs show a percentage of success but never 100 percent. So these soy results are not meant to say that every child will have early menstruation or heavy bleeding, etc. But they do tell us that enough of them do that such exposure should carries a larger than normal risk with it – and the reason researchers investigated that possibility is because the phytoestrogens in soy are at a much higher level than the hormone levels in dairy milk – and also remarkably effective at binding to human receptors, which not all hormones are. Here’s a very common sense analysis from Scientific American that offers detailed numbers that may answer some of your concerns in that regard.
My daughter now 21 had develop ovarian cysts, the doctors try to say that is genetic but I don’t believe it. Her problems started with her first menstruations.
Thanks for the interesting article. Soy is big here in northern California, but fortunately, so is breastfeeding. People who feed their infants formula do so for various reasons, not all health-related. I think it’s super important for them to understand the trade-offs before making the decision. I’m waiting for the studies on boys. I’m cynical enough to believe we won’t see much progress until it is shown that boys suffer adverse effects.
Isn’t all Soy grown with Monsanto’s seeds now? Monsanto holds the patents now on soy and corn, among others. What about Polysorbate 80 (from their herbicide Round up) being present in Soy products, including Soy formula?
My 42 yr. old daughter was on soy formula and soy milk until about 5, as she was allergic to milk. just wondering if the have study adults that were raised on soy formula?
Good question. Some of the studies (looking at fibroids, for instance) assess young women. Others, looking at menstruation, are more in the teenage years. I haven’t seen any that go into later adulthood but it would definitely be interesting and if I see any I’ll flag it. Having said that, if your daughter is basically healthy I won’t worry about this too much.
Im 65 yrs old…Drs thot I was having a reaction to mommy milk and cow milk so they put me on soy from birth…when i was 5 yrs old I started developing soft tissue calcium deposits on my legs…i was experimented on for several yrs, but found NO reason for it…when I was 9 yrs old I had my 1st period and by 11 yrs old was regular as clock work…I developed very young, hair and boobs..as I got older my cycle was 23days from start to finish…I had 2 sons and both were early..3 wks and 4wks, but were fine…when I was 38 I had already gone thru menopause, and found I had a thyroid condition, hyperthyroidism, my thyroid has nodules in both lobes…i didn’t treat, but they also said possibly calcium deposits… when I researched all this 20 plus yrs ago, said soy causes soft tissue calcium deposits, a thyroid condition can cause menopause like symptoms …i have NEVER treated for my thyroid…I go the more natural route in my health…on NO medications at all, Chiropractic and all natural supplements and NON GMO and organic eating….
Is the diet of the children considered? After infancy I mean. Were the children in the study all eating meat-based diets or plant-based diets?
I’d also like to hear more about this… And how a non-vegetarian diet with less emphasis on soy after, say, year 2 impacts child development. In other words, if the shifts they’re seeing early on can be reversed. Deborah, do you know of any longitudinal studies happening? Thanks for this really informative (and well-written!) piece!
Thanks much, Sarah. Regarding soy, my impression is that the focus of concern is in the first year or so of child development but especially during the period where soy is the sole food, as with a diet of soy formula. After that, of course, it’s only part of the diet. Following the golden rule of a healthy diet which is mix it up so as to reduce chronic exposures. My understanding from conversations with scientists at NIEHS and others is that these recent results with soy formula have driven a new kind of explosion of interest and that there are a number of more comprehensive studies being planned, including one that’s more male-female inclusive, and others that are longer term. There’s a couple of researchers, like Kristen Upson, who are doing really interesting work in this regard. I think it makes a lot of sense to follow this work further and see what really holds up. Hope that makes sense.
We adopted a baby in 1994 and felt that soy formula was the best choice. He drank the formula for almost 2 years, and we finally discontinued when our chiropractor suggested we stop the formula because he was beginning to vomit it up almost every time he drank it..It was several years later that we began to read about the hormonal effects of soy, and wondered if it could have any connection to the hyperactivity and other developmental issues we were seeing in our son…I would be most interested to know if there are any suggestions as to how to reverse any negative hormonal conditions that may have resulted from the soy formula.
If it’s helpful, everything I’ve seen related to soy and child development is focused on reproductive system issues, mostly because of the possible effects of the phyto (plant) estrogens it contains. If the Taylor study I cited is right (and it should, of course, be confirmed independently) then there may be some chemical interaction with genes. If so, the easiest thing is to just take soy out of the diet because this would be an exposure-based temporary effect. So your chiropractor gave you excellent advice.
Hello Ms. Blum,
Thank you very much for the information, very interesting. I am an environmental engineer and I am finishing a masters degree in drinking water and emerging contaminants (Pharmaceuticals, pesticides and cyanotoxins MC-LR). One of the professors who advises me specializes in environmental toxicology mentioned that another problem little addressed in terms of soy milk in the first 5 years of life is the manganese contents. This can interfere with normal neural development in children. I share two scientific publications dealing with this topic:
Manganese content of soy or rice beverages is high in comparison to infant formulas.
Manganese, Monoamine Metabolite Levels at Birth, and Child Psychomotor Development
Thanks so much for sharing that information. I knew that rice could contain high levels of inorganic arsenic and cadmium but I did not know about manganese. I really would like to come back to look at some of these naturally occurring elements in the diet so you’ve raised an excellent point here.
Thanks for this piece–it’s super important to raise awareness of this issue. Nice job here.
It is extremely rare that a baby would have a lactose intolerance since breastmilk is full lactose, what you mean is a cows milk protein allergy or intolerance about 1% of breastfeed babies have it and about 3-7 % of formula feed babies. Two different things. If you made this simple mistake I’m wondering what else you didn’t get right in your article. That being said thanks for writing it and I will be sharing it.
Yes, I emphasized lactose because it is a sugar found in all mammalian milk. Ran that fact by a scientist who agreed that it’s a broad spectrum issue. But you are absolutely correct that the issue with milk-intolerance is often related to protein and may be even bigger. Sorry if it sounded confusing and thanks for the additional clarification.
True inability to digest lactose is extremely rare in am infant and suggests inability to produce lactase. This inability can naturally occur post weaning hence higher levels of lactose intolerance among adults. Cows’ milk protein allergy as the above answer states is far more common and can also manifest itself in breastfed infants if the mother consumes dairy. Lactose intolerance in a baby is rare, serious and incompatible with breastfeeding, CMPA isn’t if the mum cuts out dairy.
I see a lot of mothers who are confused about this and their doctors are too, so I think it’s important to make the distinction.
It’s a very interesting article. I wonder how the long term effects compare to those of dairy formula – diabetes, obesity etc. Interesting area.
Soy products have been used in Dairy cattle milk replacements.
Could a transcriptome model be created in calves/piglets be used as a model for humans?
Transcriptome analysis reveals persistent effects of neonatal diet on the ileum gene expression in porcine neonates
MinION is a cheap DNA analysis tool. Can it be used to model transcriptomes.
MinION is used for agriculture and blood diagnostics.
Could the aging of tissue show differences?
I don’t know that there is a great vegan alternative regarding formulas. And maybe we’re at a point that we should encourage formula makers to look at other protein-rich beans as a source. I’m not dismissing soy’s importance in the diet as we get older, only making the case that it may pose problems during the critical developmental period, from zero to six months at a minimum. If it wasn’t too much of an ethical conundrum, I’d lean toward a breast/cow milk formula diet until the point when more solid foods are possible. But I do get that’s a personal decision.
I don’t think by pointing out that soy is a dodgy choice that it’s now the authors responsibility to provide a vegan friendly alternative.
Breastmilk is a vegan alternative better support would prevent the need for such formulas on such a wide scale also Donor milk is available in the UK and US and would be much better for baby than any formula
Babies are not designed to be vegetarian or vegan. They are designed to drink mammal milk. So any plant alternative is going to have issues.
They are “designed” to drink HUMAN milk… not cow’s milk or any other mammalian milk other than their own species.
Protein in the diet is highly overrated, and especially in that of an infant. It’s fat that the growing infant needs. If you look at the composition of breast milk it is contains over 55% fat and only about 6% protein with the rest being carbs. You can easily make your own infant formula’s using coconut milk and some high quality fats, just search around for recipes. This idea that we need to be feeding infants high amounts of protein is just simply incorrect. When in doubt, look to nature!
I have been eating soy products for more than 20 years, and write about science, so I naturally wonder about the phytoestrogen connection. I try to vary my diet so that I’m not mainlining tofu on a daily basis, for example. Whatever its effects were during my fertile years, which ended 8 years ago, seem only to have been positive (e.g., an easy menopause). But that’s just me, and I was never tested, ergo, inconclusive, of course.
This is an important article, especially for parents of young children of either sex. People of all dietary persuasions can get carried away with the magic bullet effect of certain foods. We cannot forget we are omnivores, primed to seek variety for some very, very good reasons, and can get into trouble if we act like koalas and try to specialize.
One thing missing from this discussion (I hope only due to lack of space): the hormone load of feedlot (versus free-range, grass-fed) cows. Were the studies years ago of extremely early onset menarche in Costa Rican (?) girls just anecdotal and not worth pursuing? Surely having hormones (along with so much else) pass from meat to meat-eater will effect the eater’s biochemistry.
yes , there is research – Maureen Minchen’s book Milk Matters – looks at the dairy industry and faormula – If cow’s are being fed hormones to produces more milk etc then cow’s milk formula must also contain hormones – babies are fed large quantities of this from day one , at least 6 times a day , –
So surely one of the long term term effects could be hormonal disorders ?
By not drinking species specific milk from birth the body has to adapt to another species milk – at what cost to the body ?
Hi Louise – Thanks so much for your very thoughtful response. I did focus pretty specifically on the phytoestrogen factor with soy formula, partly for reasons of length and partly because it’s not an issue that gets enough attention (I think) so I wanted to explore it in some depth. It is true that different diets can affect the hormone load both in cow and breast milk so that’s a good point. But the studies I looked at noted that even in those cases, the estrogen loading in soy remains at a level some 2,000 times that of other forms of milk (compared to more than 4,000 in the “cleaner” comparison.) The real issue to me is trying to make parents aware that there is this potential to alter the normal development of the reproductive system so that they can factor that into their decisions. Thanks so much for writing.
Thanks, Deborah. That makes a lot of sense.
I am quite shocked to read it’s 2000 times!
I agree that parents should be aware of the risks.
Not a parent myself, but have to empathize with new parents, in particular, trying to navigate all the advice their families give them as well as whatever science appears in popular press. As you know, what filters down to the newspapers doesn’t always provide solid guidance, and can lead to info overload and a kind of numbness.
As for ingesting hormone disruptors: I shudder to think of what horrors lie down the road when evidence of *synergistic* effects come to light. In ourselves and in other species.
Yes, I wonder about synergies too. We really do have so little information about so many of the materials we introduce into your systems. Because I’m a toxicology writer, I’ve tended to take an increasingly pragmatic approach. Be as aware as possible (hence my story on the underreported effects of soy) and protect yourself against the risks that seem most worrisome, which for me would be things like lead or mercury, arsenic, cadmium, some of the long-lasting compounds like early-generation flame retardants. And not make yourself too crazy:) It’s a chemical world out there and we just need to learn how to be as smart as we can in navigating it. Hope that makes sense!