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She did not die of cyanide poisoning…how can jurors be so stupid? Because of his research on his computer…If a test is wrong, it’s wrong. If she had died of cyanide…she would have died immediately…not hung on for days with no symptoms of poisoning except the blood issue which can be caused by heart issues….but because he researched cyanide and ordered cyanide…he was convicted…
What a waste of humanity…what stupid jurors….how can something so simple not be apparent to them at trial….they wanted someone to pay…so he is paying….what a waste…why did the judge not order independent testing? Because our stupid legal system won’t allow it…what a waste.
Bravo, Cathie. You are exactly right. No cyanosis, no swift death, no lung frothing, and no futile resuscitation efforts. (In the ambulance, she has actually revived quite easily, a feat impossible with cyanide poisoning.) May this poor man get a chance at relief through a post-conviction act filing. I blame the Medical Examiner for not realizing the facts do not fit together.
Cyanide poisoning does not cause cyanosis (blue palor). Just the opposite. Cyanide stops cells from using oxygen, so venous blood is bright red. Cells resort to lactic acid fermentation, so acidosis. (this is bio 101 stuff people!) The highest demand organs are brain (headaches) and heart (heart failure). The medical signs match cyanide poisoning!
So you admit that CN deprives the body of oxygen? Good. So you know that once CN is in the bloodstream NO OXYGEN IS AVAILABLE to the heart and other organs. Right? So why was she so easily resuscitated? Cyanosis is only absent when the victim dies quickly or when the dose is very low. Neither of these facts apply to Autumn Klein. Supposedly, the amount of CN detected by Quest was lethal, at 15hrs after consumption, yet she lived for 3 days. Logically, cyanide must not have been present at all. They imprisoned an innocent man.
Concluding that cyanide poisoning caused death from the presence of “acidosis” is like concluding someone has HIV from observing them sneeze.
Autumn Klein was diagnosed with a mitochondrial disorder while she was still alive, and she experienced migraines and auras in the weeks before she died. For those who think her collapse could be nothing but cyanide, please read this description of mitochondrial disease symptoms: https://ghr.nlm.nih.gov/condition/mitochondrial-encephalomyopathy-lactic-acidosis-and-stroke-like-episodes
“Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a condition that affects many of the body’s systems, particularly the brain and nervous system (encephalo-) and muscles (myopathy). The signs and symptoms of this disorder most often appear in childhood following a period of normal development, although they can begin at any age. Early symptoms may include muscle weakness and pain, recurrent headaches, loss of appetite, vomiting, and seizures. Most affected individuals experience stroke-like episodes beginning before age 40. These episodes often involve temporary muscle weakness on one side of the body (hemiparesis), altered consciousness, vision abnormalities, seizures, and severe headaches resembling migraines. Repeated stroke-like episodes can progressively damage the brain, leading to vision loss, problems with movement, and a loss of intellectual function (dementia).
Most people with MELAS have a buildup of lactic acid in their bodies, a condition called lactic acidosis. Increased acidity in the blood can lead to vomiting, abdominal pain, extreme tiredness (fatigue), muscle weakness, and difficulty breathing. Less commonly, people with MELAS may experience involuntary muscle spasms (myoclonus), impaired muscle coordination (ataxia), hearing loss, heart and kidney problems, diabetes, and hormonal imbalances.
“Boctone Scientist” aka “Boston Scientist” seems to willfully ignore facts & the chronology.
At 11:18 pm on April 17, 2013, video surveillance established that Autumn Klein left her work at UPMC Presbyterian.
At 11:52 pm, Robert Ferrante placed a 911 call, stating that his wife had “just got home from work”, then collapsed, staring, breathing normally, and that these symptoms started “10 minutes, maximum”. During the 911 call, Autumn Klein could also be heard grunting & moaning in the background. The 911 call lasted 11 mins, 55 secs.
During the trial, several work colleagues testified that Robert Ferrante told them he prepared a drink for Autumn Klein with creatine in it, and she drank it before collapsing. In a text message exchange earlier that day, Autumn Klein wrote, “I have an aura. According to my calendar, I ovulate tomorrow.” Robert Ferrante replied, “Perfect timing. Creatine :0)” and “I’m serious. It will make a huge difference. I certain.”
When paramedics arrived, they found Autumn Klein lying on the kitchen floor next to a gallon-Ziploc bag of powder and a small glass vial on the kitchen counter. Robert Ferrante told paramedics the Ziploc contained creatine to help her with fertility.
While on the stand, Robert Ferrante denied that Autumn Klein ever drank anything when she arrived home.
After the paramedics rushed her to UPMC Presbyterian, Autumn Klein had a treatment team that included a neurologist, cardiologist & ICU physician. When all her other labs came back normal, her cardiologist ordered a toxicologic screen for cyanide due to “profound acidosis on initial arrival”, and her oxygen levels were in the five hundreds. B.S. conveniently ignores those lab results, as well as the undisputed fact that Klein’s cardiologist ran a toxicology screen for cyanide while she was still alive.
During the trial, three different tests were presented into evidence that confirmed cyanide was present. The two Quest lab test results reflected a fatal dose of cyanide (2.2 mg/L and 3.4 mg/L).
A conflicting NMS forensic lab test result reflected a background/non-fatal dose of cyanide (.5 mg/L). Notably, the NMS forensic lab test was paid for by the defense. The NMS test couldn’t be completed because a piece of equipment needed to examine the precise level of the poison in Klein’s blood wasn’t working and because the control came back negative, indicating that the test being used wasn’t reliable. Eventually, NMS did find a cyanide metabolite — a substance created when the poison is broken down in the bloodstream — but only the .5 mg/L level that could normally occur in a person’s blood.
It’s also an undisputed fact that Robert Ferrante ordered a bottle of potassium cyanide on April 15 for overnight delivery. It’s a further undisputed fact that Robert Ferrante’s fingerprint was found on the opened bottle of potassium cyanide & 8.3 grams were missing from the bottle.
None of Robert Ferrante’s research projects ever called for cyanide. His research assistant Jinho Kim, testified that the only time Ferrante mentioned cyanide for a project was after the bottle arrived on April 16. When the bottle arrived, Kim asked whether the bottle should be locked up, and Ferrante instructed Kim to store it under his bench. Kim further testified that the only time he saw the bottle again was after the police investigation, when the bottle was discovered in the lab refrigerator.
During trial & on the stand, Ferrante testified that he had never used cyanide for his research and that he ordered the cyanide was for a future project.
It’s also an undisputed fact that from January 2013 until days before Autumn Klein collapsed, Robert Ferrante’s personal MacBook had dozens of Google searches relating to cyanide and human toxicity, and how a medical examiner can find cyanide in a body. One of the searches typed into Yahoo Answers on his computer was, “How would a coroner detect when someone is killed by cyanide?” Other searches included “divorce in PA”, “this is what a heart attack feels like to a woman”, and one search on his computer was, “malice of forethought”. Malice aforethought is the legal standard of proof to establish a premeditated killing.
The only appropriate conclusion to this mountain of evidence is the guilty verdict & conviction, which were also confirmed after multiple appeals.
None of Robert Ferrante’s research projects ever called for cyanide. His research assistant Jinho Kim, testified that the only time Ferrante mentioned cyanide for a project was after the bottle arrived on April 16. When the bottle arrived, Kim asked whether the bottle should be locked up, and Ferrante instructed Kim to store it under his bench. Kim further testified that the only time he saw the bottle again was after the police investigation begun, when the bottle was discovered in the lab refrigerator. As soon as he discovered the bottle had moved, he notified lab administrators, who reported the incident to university police.
During trial & on the stand, Ferrante testified that he had never used cyanide for his research and that he ordered the cyanide for a future project.
Let me do the math for you: The sample that tested positive was drawn at 14:40, just over 15hrs after supposed ingestion. At a half-life of 10mins, that calculates to 90 half-lives. At T1/2 =30mins, the 30 half-lives would have elapsed. The level measured was 2.2mg/L. So 2.2mg to the power of 30 calculates to ~18 metric tonnes per liter. See? The math is absurd. The timeline is inconsistent with the known pharmacology of cyanide.
It is amazing how facts get twisted. Quest only performed ONE test. They did a math error the first time and got the higher value, but adjusted the math and got 2.2mg/L. This was from the same test, the same sample. A second sample, drawn 40mins after the Quest sample, was sent to NMS, and this test measured NEGATIVE for thiocyanate. Your statement about how to interpret their data is erroneous. It means “below detection,” i.e. negative.
So you either have to accept (1) that the Quest reading was actual cyanide CN- and thus conclude Autumn Klein consumed several metric tonnes of it (absurd), or (2) Quest measured thiocyanate, SCN- the metabolite, even though only 40mins later, NMS measured none of it, or (c) Quest measured something else.
That something else is malondialdehyde, a by-product of heart and kidney failure known as the “TBARS response.” This is the same false positive behind the Urooj Khan case, and others.
Your comments about the NMS sample and testing are wrong. The first time the sample was run, the positive control failed, so they threw out the results. The SAME sample was re-run two weeks later (after an instrument delay), and was run successfully, showing NEGATIVE for thiocyanate. According to standard procedures, a sample is stable in the freezer for 6months. The NMS data is completely valid.
It is the Quest test that is suspect. Unlike NMS, who run LC/MS, Quest uses a decades-old method based on a multi-step colorimetric reaction. Malondialdehyde cross-links the reagents, short-circuiting the chemistry that otherwise can be catalyzed by cyanide. Mayo Clinic declared this “pyridine-barbiturate” method to be obsolete.
You are absolutely off base. She had just about every symptom of cyanide poisoning one could have. Headache, dizziness, a few others followed by cardiac arrest, loss of consciousness, low blood pressure, slow heart rate, and seizures. The latter of the symptoms will start a few minutes after ingestion which is exactly what happened here. Remember? There was a bag of powder on the counter where she had been standing. Depending on the amount ingested, will determine how long it takes till your completely braindead. She was able to receive life saving treatment quickly, and this allowed her body to continue functioning even if her brain wasn’t functioning. Also, bright red blood from a vein most likely means the blood is acidic. Abnormal oxygen and acid levels in the blood are an indicator of cyanide poisoning, which happened with her as well. Lastly, all of the things I’ve said here along with a positive result on her toxicological screening means she died of cyanide toxicity! I know this because I work in the medical field and have had years and years of training. I don’t see how you can responsibly say it’s not cyanide toxicity if you don’t know anything about it.
You need to look up the symptoms of cyanide. They are: mouth frothing, cyanosis on face and extremities, blackened stomach, convulsions and swift death. Autumn Klein had NONE of these. NONE. A blood sample drawn soon after admittance was measured for thiocyanate, and it showed NEGATIVE. That means there was no cyanide. The sample sent to NMS (detected by LS/MS!) also returned NEGATIVE. Only the sample sent to Quest returned positive, and it was a colorimetric test, obsolete decades ago. The sample sent the Quest was drawn >15hrs after admittance. Cyanide has a half-life of 10-30mins, so no cyanide should be detected within a few hours, unless it kills you first. The mere fact that cyanide was detected so late in the timeline proves it was a false positive. Karl Williams, medical examiner, railroaded an innocent man. (This author Paula Reed Ward did a pretty good job at railroading, too.)
Cyanide kills by starving the blood cells of oxygen. No amount of resuscitation can help them, since it is not the lungs or heart that is the cause of the problem, but the blood. No cyanide poisoning victim ingesting a large amount of cyanide has ever survived in time to reach the hospital. Only a tiny few cases of people ingesting trace amounts (by air) who were rushed to hospital still conscious and administered with antidote, have ever been resuscitated. So please tell me, how did the paramedics who attended Autumn Klein, and who did NOT administer an antidote, resuscitate her so easily in the ambulance, given that she had taken a lethal dose? Isn’t it more likely she had heart failure?
“Headache, dizziness, a few others followed by cardiac arrest, loss of consciousness, low blood pressure, slow heart rate, and seizures.” – Actually, honey, these are just general symptoms that could apply to kidney failure, heart failure, alcohol poisoning and even paracetamol overdose. Hell, I have almost all those symptoms (except seizures) on a yearly basis from nothing. The symptoms of cyanide are very, very distinct. If you saw a cyanide poisoning victim, there would be no doubt about it. But there is plenty of doubt here. Try going to PubMed and looking up Case Reports of cyanide fatalities. You will see the symptoms do not match Autumn Klein at all.
Compare Autumn Klein’s death to this case: http://medind.nic.in/jbc/t12/i2/jbct12i2p104.pdf In this report, the victim inhaled a small quantity of cyanide (smaller than what Autumn Klein would have ingested, if it really were cyanide). This report describes cyanosis, lung frothing, and stomach blackening, together with swift death. Autumn Klein had none of these symptoms. Only metabolic acidosis is common to both, but acidosis is a general response, and can be induced by a wide range of factors. At trial, the prosecution expert said Autumn Klein’s symptoms could be consistent with very low dose of cyanide, but according to their diagnostics, she did not ingest a small quantity. Supposedly, she had a lethal concentration in her blood 15hrs later, so why, unlike ALL THE OTHER VICTIMS, did she not die quickly? Answer: Because cyanide was never present.
Does Paul Reed Ward deserve any blame for helping railroad this innocent man? She wrote fantasies about the Ferrante and Klein marriage, and made explicit statements about Robert Ferrante being a master manipulator. Almost certainly, these statements influenced the trial. She even repeats the lie that the sample that tested positive for cyanide was drawn soon after Autumn Klein was admitted to hospital. (In fact, this sample was drawn 15hrs later.) So, does Paul Reed Ward deserve blame for helping to convict an innocent man?
How saddening it is to see others rush to judgment based on their interpretation of behavior. Just wow! Meanwhile actual details indicate that Autumn Klein could not have died of cyanide poisoning. The pharmacology is wrong, and so are the presented medical symptoms. Funny how people can’t see the trees for the forest. She died of a heart attack, people! How obvious does it have to get? Symptoms match, timeline matches, diagnostics match – all except one, yet somehow the morons at the Medical Examiner’s Office believe that one outlier.
Sorry…but the guy is guilty. Insisting to not do an autopsy ? Serious red flags.. What if she had a genetic disorder that the daughter could get. Constantly interrupting others with his own diagnosis…the same thing? Ya…I’d be pretty suspicious of him too.
The symptoms are all wrong for cyanide because she never had any, exactly as you say! She was unconscious, and in the midst of a heart attack. Cyanide causes frothing at the mouth, convulsions, a dark red (cherry) color change to the face and hands, and most importantly, it causes quick death, with no possibility of resuscitation. Yet none of these things applied to Autumn Klein. None. The prosecution tried to dismiss their absence as being due to such a small amount of cyanide, but their own data do not support a “small amount.” Furthermore, the half-life is completely wrong. Quest supposedly measured 2.2mg/L cyanide 16 hrs after Autumn was admitted, including 8 hrs on dialysis. Cyanide is known to have a half-life of 10-30mins, after which it mostly decays to thiocyanate. You do the math! NMS measured zero thiocyanate. It is impossible. The pharmacology is completely wrong. Thirdly, Quest Diagnostics uses a colorimetric test that is almost identical to a “TBARS” test that measures products of heart and kidney failure. This is the source of the false positives for Urooj Khan, Mei Xiang Li, Janet Overton and others who all died without cyanide poisoning symptoms. Robert Ferrante is a wrongfully convicted man, railroaded by just about everybody. I hope one day the courts will look at the evidence properly.
“i have discovered.”? This implies that you were involved in the case, probably as one of the expert witnesses for the defense. If so, I would respect your opinion because must have significant medical and scientific qualification to be involved in the case. On the other hand, you also would tend to be at least somewhat biased toward your own interpretation. I am sure that the prosecution experts would say differently.
Like Will Rogers, all I know is what I read in the newspapers (well, and internet). But I don’t think the “symptoms” are “all wrong.” Technically, neither the the EMT’s nor the doctors at the hospital ever got the see the “symptoms” because symptoms are what the patient tells the doctor (or other health care providers). The only person who really knows the symptoms is her husband. She was unconscious when the EMT’s found her and she never regained consciousness. The totality of the medical “signs” and other objective evidence point to cyanide poisoning within the usual medical/biological uncertainty. The unusually bright red venous blood suggests that in itself. We rarely can be 100% sure about anything, but the story seems quite convincing for cyanide poisoning.
By the way, if a loved one of mine died mysteriously, I would demand an autopsy. Having the body cremated seems extraordinarily suspicious in itself. .
Clearly, Autumn Klein never died of cyanide poisoning. The symptoms are all wrong, the timeline inconsistent and the dosage impossible. This is a false positive, (one of five I have discovered) and Robert Ferrante is a wrongfully convicted man. This author’s newspaper articles did a lot to defame him and turn public sentiment against him, even though he was an innocent man caught in a family tragedy with zero history of unlawful behavior or even of a troubled personality. He spent his life dedicated to humanity, but the fantasies of journalists kicked him down anyway.