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Prozac and the other serotonin uptake inhibitors are interesting. The author is correct that fluoxetine was demonstrated to increase suicidal thoughts, but not suicides. Several areas in the US saw large drops in prescribing of the serotonin uptake inhibitors (SUI is accurate, SSRI is Pharma hype) as did the Netherlands. And there was a corresponding large increase in teen suicides. Ooooooops!
Talking about suicidal thoughts is good. Suppressing such thoughts is bad. I wish that I could find the papa ER, but about 1990 a study was done that compared Ph.D. Psychologists and M.D. psychiatrists with high school seniors as the control group. They were given admission papers for 100 consecutive adult patients to a psychiatric hospital and asked to pick out the patients who subsequently committed an act of violence against staff or other patients. The three groups picked out the same admits and were all wrong—so much for all that time spent training. Patients who voiced that they felt like hurting someone were picked out. The ones who did act violently were the ones who had committed an act of violence prior to admit, but denied any feelings of violence or aggression. Expression of thoughts and ideations is good. Not understanding this cost many lives.
15 years ago after a prostate biopsy(negative) I came down with the Flu and days later severe prostatitis. My urologist proscribed a long course of the antibiotic Cipro. Weeks later my feet developed intense pain in the arch and heel bone (calcaneus), diagnosed as plantar fasciitis, which I had never had before. The foot pain vanished immediately as soon as I finished taking the Cipro and has never recurred. A rugged friend suddenly developed an achilles tendon separation putting him in a cast for several months. It turns out he had been taking Cipro for some unrelated but minor condition. I informed CDC that there were 2 cases of probable dangerous musculo-skeletal side effects from Cipro. CDC responded with the comment they had received many reports of musculo-skeletal problems associated with Cipro. I heard nothing further from CDC and Cipro is still widely proscribed, without warnings issued. Trained as an EMT, I strongly suspect wholesale corruption within the American Medical Profession and the Pharmacologic Industry, following the same corrupt developments within American Government.
just FYI – there has been a FDA ‘black box’ warning on Cipro (and the other fluoroquinolone drugs) for many years now. The medical community is well aware of the risk of musculoskeletal issues, particularly tendon rupture.
I too developed plantar fasciitis, ad well as inflamed Achilles’s tendons, while taking Cipro, but did recover after several months. My husband did not fare as well, developing “Ideopathic” Peripheral Neuropathy before he was 30. He is now 47 and on complete disability.
Actual cause of SMON still unknown; viral etiology still under consideration. Ito M, Nishibe Y, Inoue YK (1998). “Isolation of Inoue-Melnick virus from cerebrospinal fluid of patients with epidemic neuropathy in Cuba”. Arch. Pathol. Lab. Med. 122 (6): 520–2. PMID 9625419.
Superb article. I’ve been researching SSRIs for almost 12 years now (fiddaman.blogspot.com) and it’s difficult to single out who is responsible for allowing, nae ignoring the suicidal and homicidal adverse events. Do we blame the drug companies, the medicine regulators or the prescribers?
I was recently at the trial of Stewart Dolin Vs GlaxoSmithKline (GSK). Stewart had taken a generic version of Paxil, shortly after which he jumped in front of a train. The jury found for the plaintiff, his wife, who had filed the suit against GSK.
What was remarkable about this trial was the evidence shown (for the first time)
During the Paxil clinical trials, it was learned that 22 adults (over the age of 30) died, 20 of whom died by suicide. All 20 were taking Paxil.
GSK and medicine regulators around the world kept this “in-house”. Years later, GSK and other drug companies, along with the FDA, were forced to include a black box warning on antidepressants that warned of increased suicidality in children and adolescents. Nowhere on the black box does it give the same ‘stringent’ warnings to adults.
I wrote to the British drug regulator (The MHRA) to ask if any children or adolescents had died in Paxil clinical trials. ‘No’ was the answer.
It seems quite bizarre then that an increase in suicidality warning for children and adolescents would be placed on the labels of SSRIs when it’s the adults at risk.
Of course, GSK et al could not warn of an increase in suicidality in adults because this would mean fewer sales. Let’s face it, if the drugs can cause suicidality in adults then it stands to reason that kids could be harmed by it too. So the drug companies and regulators took away a portion of these sales by claiming it was only children and adolescents who were at risk.
So, when I’m asked, “Who do you blame?” the answer isn’t really that simple. I lay a lot of the blame on the regulatory bodies, the MHRA, for example, have an incestuous relationship with GSK. The current CEO of the MHRA is Dr. Ian Hudson who was previously the World Safety Officer at SmithKline Beecham (GSK’s name before the merger). Before him was the then Chairman of the MHRA, Alisdair Breckenridge, he was also an ex-employee of GlaxoSmithKline.
The revolving door that exists between drug companies and medicine regulators is, to be frank, quite nauseating. We will always have drug problems if we continue to allow the fox to guard the henhouse.
When I was young and speed was legal , I was prescribed it by a gynecologist. I took it for about five years before it was outlawed. It caused a lot of problems for me and I had no idea until much later that the drug was causing the problems. Now I won’t take any drug that is new. They have to be more than seven years on the market or not for me. I have no faith in the drug industry or in doctors who love them. After firing many doctors I now have some that are as suspicious of new drugs as I am , at least for me. I get black hives all over my body from Eliquis. White hives from all the statin drugs. And many other side effects from other drugs. Some just make me confused and drunk. I can’t drink alkahol either, I don’t have the enzyme that allows other people to digest it. Three day hangovers from a glass or two of wine with dinner are no fun. I find that aspirin for blood thinning works just fine as long as I eat something with it, and it is a lot cheaper. I have found work arounds for most of my health problems and pain is helped substantially with heat or cold or my vibrating bed. I have terrible asthma and that does require prescription inhalers. So the drug industry does contribute a little to my continuing life.
Fascinating article, can’t wait to start reading your book, and kudos for taking on this topic, and especially, the dangerous device industry. I have way too much experience with “cure as cause” in medicine, and equally if not more, in dentistry. That is worthy of an entire book as well – perhaps an entire encyclopedia (for those who remember what they were), or an entire library.
Could you give any examples of dental mishaps? I think I might have suffered some myself, wanted to compare notes. I had a filling fall out of the same tooth many times- that tooth then required a root canal, crown, then they said they wanted to redo the crown, then they wanted to take it out and put in an implant. WHEW- so much money down the drain!
I used Cpap. I did not have central sleep apnea until several months after starting treatment. I seriously believe the treatment cauzed the CSA . They never list it as a side effect.
The use of a CPAP does not cause sleep apnea. Your claim is false.
Interesting article! In my mid 20’s I had an aweful experience with Sleep Paralysis and began suffering with panic attacks fearing that it could occur again. I was prescribed Prozac and Celexa to treat my anxieties however, the buzz at the time was that the medications could lead to suicidal thoughts. None of which I had ever had as I was a happy positive person who received great support from my family and my boyfriend. I didn’t reveal to anyone that I was prescribed Prozac or Celexa since it was taboo. That would have created a shock value to my family and friends that something was mentally wrong with me. I never took the medication because I had feared that it would spin my mind out of control. So with each panic attack I decided to “cure as cause”(as I now can name it from your article) until to was able to maintain my anxieties. It’s been a quite a long time since my last episode and sometimes it is indeed best to “cure as cause”. Thank you for your eye opening article!
?? That’s not at all what is meant by “cure as cause”.